As clusters continue to grow in size and complexity, providing scalable and predictable performance is an increasingly important challenge. A crucial roadblock to achieving predictable performance is stragglers, i.e., tasks that take significantly longer than expected to run. At this point, speculative execution has been widely adopted to mitigate the impact of stragglers. However, speculation mechanisms are designed and operated independently of job scheduling when, in fact, scheduling a speculative copy of a task has a direct impact on the resources available for other jobs. In this work, we present Hopper, a job scheduler that is speculationaware, i.e., that integrates the tradeoffs associated with speculation into job scheduling decisions. We implement both centralized and decentralized prototypes of the Hopper scheduler and show that 50% (66%) improvements over state-of-the-art centralized (decentralized) schedulers and speculation strategies can be achieved through the coordination of scheduling and speculation.